You can use cosmetics to cover up some facial flaws, but if you have acne on your face, you cannot completely hide it. You may feel that you have no way to conceal your imperfections from a world that judges you based on your appearance. Severe acne can have a significant impact on social relationships and affect a person’s confidence and self-esteem in a way that leads to depression — particularly during the teenage period. Depression is very common in people with severe acne, who may feel especially self-conscious about their skin.